Septum primum development

Across TCGA cell cohorts, RNA activity of the Septum primum development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHST12, GPAM, and PIP5KL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHST12 grouped by Septum primum development-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CHST12 →	-1.073	-1.451	.001	.002	3	5
BLOOD_Leukemia	GPAM →	+0.922	+1.379	.002	<.001	3	4
LUNG_NSCLC_LUAD	PIP5KL1 →	-0.889	-0.626	.003	.002	3	4
BREAST	TAS2R5 →	-0.413	-0.896	.006	.004	3	4
BREAST	MALL →	+2.156	+0.962	.003	.003	3	4
OVARY	GPR132 →	-0.601	-0.949	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHST12 by Septum primum development activity — BLOOD_Myeloma

Explore this box plot interactively →