Septum primum development

Across TCGA pan-cancer cohorts, RNA activity of the Septum primum development pathway differs between tumor and matched normal tissue in 11 of the 18 cancer types tested.

The strongest signal is observed in thyroid carcinoma (THCA), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors.

THCA, LIHC, and BLCA show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
THCA	All	II,III,IV	+0.052	<.001	8	view →
LIHC	Female	All	+0.056	<.001	7	view →
BLCA	All	III,IV	+0.069	.014	5	view →
STAD	Male	II,III,IV	+0.084	<.001	4	view →
HNSC	All	All	+0.035	.013	4	view →
CHOL	All	All	+0.157	<.001	3	view →
ESCA	All	II,III,IV	+0.185	.003	2	view →
UCEC	All	All	+0.068	<.001	2	view →
KIRP	All	IV	+0.062	.014	2	view →
PRAD	All	All	+0.019	.035	2	view →
LUAD	Male	All	+0.054	.011	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 11 strongest of 11 lineages.

GO:0003284–THCA

Open the THCA breakdown →