Cardiac septum development

Across TCGA cell cohorts, RNA activity of the Cardiac septum development pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF18, USP20, and LTBP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGEF18 grouped by Cardiac septum development-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ARHGEF18 →	-0.825	-0.426	.004	<.001	2	5
STOMACH	USP20 →	-0.593	-0.415	.002	.008	3	3
STOMACH	LTBP3 →	-2.523	-0.593	.002	.008	3	3
STOMACH	ZFP3 →	-1.184	-0.426	.001	.006	3	3
BLOOD_Lymphoma	PI3 →	-0.313	-1.818	.009	<.001	2	4
BLOOD_Lymphoma	USP54 →	-1.290	-1.412	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGEF18 by Cardiac septum development activity — STOMACH

Explore this box plot interactively →