Endocardial cushion formation

Across TCGA patient cohorts, RNA activity of the Endocardial cushion formation pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM204, PDGFRB, and EDNRA, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocardial cushion formation activity versus TMEM204 in THYM (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	TMEM204 →	+1.645	+0.051	<.001	<.001	3	32
HNSC	PDGFRB →	+1.747	+0.063	<.001	<.001	3	31
TGCT	EDNRA →	+1.994	+0.095	<.001	<.001	3	31
MESO	HEYL →	+1.768	+0.064	<.001	<.001	3	31
UCS	FBN1 →	+2.218	+0.098	<.001	<.001	3	31
THYM	F2R →	+2.003	+0.053	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003272 vs TMEM204 — THYM

Explore this scatter interactively →