Endocardial cushion formation

Across TCGA pan-cancer cohorts, RNA activity of the Endocardial cushion formation pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 31 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Endocardial cushion formation pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCEC and UVM, show the opposite pattern, with higher activity associated with better survival.

KIRP, MESO, and COAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.570	0.755	<.001	159	view →
MESO	OS	Median	All	0.271	0.475	<.001	55	view →
COAD	DFS	Tertile	II,III,IV	0.552	0.716	.003	54	view →
LIHC	DFS	Tertile	All	0.234	0.517	.003	33	view →
UCEC	DFS	Tertile	II,III,IV	0.876	0.739	.005	28	view →
STAD	OS	Tertile	All	0.413	0.663	.029	27	view →
UVM	OS	Tertile	II,III,IV	1.000	0.674	.011	17	view →
OV	OS	Tertile	All	0.801	0.888	.025	14	view →
SCLC	DFS	Median	II,III,IV	0.205	0.819	.004	13	view →
ESCA	DFS	Tertile	IV	0.242	0.628	.024	12	view →
BLCA	OS	Median	All	0.209	0.500	.010	10	view →
THCA	OS	Median	II,III,IV	0.959	1.000	.008	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0003272–KIRP (OS)

Open the KIRP breakdown →