Endocardial cushion formation

Across TCGA cell cohorts, RNA activity of the Endocardial cushion formation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LDAH, TOP2A, and SLC9A6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocardial cushion formation activity versus LDAH in OVARY (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LDAH →	+2.141	+0.436	.003	.004	3	4
BLOOD_Leukemia	TOP2A →	+1.065	+0.869	<.001	.002	3	4
LUNG_NSCLC_LUAD	SLC9A6 →	+0.971	+0.366	.002	.003	3	4
BLOOD_Leukemia	PLEKHA5 →	+2.051	+0.909	.001	.003	3	4
BREAST	TNFAIP8 →	+2.105	+0.430	<.001	<.001	3	4
LIVER	HNRNPK →	+0.335	+0.362	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003272 vs LDAH — OVARY

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