Cardiac atrium development

Across TCGA cell cohorts, RNA activity of the Cardiac atrium development pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFT52, ADTRP, and TACC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IFT52 grouped by Cardiac atrium development-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	IFT52 →	-0.889	-1.065	.006	.004	3	4
LIVER	ADTRP →	-1.857	-1.275	.001	.006	3	4
STOMACH	TACC2 →	+1.607	+0.779	.001	.009	3	4
STOMACH	SOAT1 →	-1.603	-0.760	.007	.002	3	4
URINARY_TRACT	CCN1 →	-3.166	-2.008	.005	.001	2	5
BLOOD_Lymphoma	FKBP1B →	-1.277	-1.578	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IFT52 by Cardiac atrium development activity — OESOPHAGUS

Explore this box plot interactively →