Cardiac atrium development

Across TCGA pan-cancer cohorts, RNA activity of the Cardiac atrium development pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 37 member genes.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher Cardiac atrium development pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and THYM, show the opposite pattern, with higher activity associated with better survival.

DLBC, HNSC, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Tertile	All	0.398	1.000	.001	45	view →
HNSC	DFS	Median	III,IV	0.745	0.622	.008	41	view →
ACC	OS	Quartile	II,III,IV	0.126	1.000	.001	39	view →
THYM	DFS	Median	All	0.923	0.615	.003	34	view →
MESO	OS	Median	IV	0.311	0.737	.004	30	view →
STAD	DFS	Median	All	0.615	0.787	.008	24	view →
UCS	DFS	Median	II,III,IV	0.599	0.294	.009	20	view →
ESCA	OS	Tertile	IV	0.398	0.743	.024	18	view →
BLCA	DFS	Median	All	0.692	0.497	.009	15	view →
LIHC	DFS	Median	II,III,IV	0.233	0.411	.018	15	view →
SKCM	DFS	Tertile	III,IV	0.435	0.697	.004	10	view →
BRCA	DFS	Tertile	III,IV	0.952	0.826	.014	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0003230–DLBC (OS)

Open the DLBC breakdown →