Ventricular trabecula myocardium morphogenesis

Across TCGA cell cohorts, RNA activity of the Ventricular trabecula myocardium morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RALGAPB, CASC3, and SQOR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RALGAPB grouped by Ventricular trabecula myocardium morphogenesis-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RALGAPB →	-0.778	-0.834	<.001	.003	3	5
LUNG_SCLC	CASC3 →	-0.578	-1.017	.002	.006	3	5
STOMACH	SQOR →	+2.317	+1.108	<.001	.002	2	5
STOMACH	NIM1K →	-0.161	-1.113	.003	.003	3	4
BREAST	MED24 →	-1.384	-1.057	.006	.001	3	4
URINARY_TRACT	FAH →	+1.719	+0.412	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RALGAPB by Ventricular trabecula myocardium morphogenesis activity — OVARY

Explore this box plot interactively →