Cardiac left ventricle morphogenesis

Across TCGA cell cohorts, RNA activity of the Cardiac left ventricle morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THAP12, MSMP, and CPE, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac left ventricle morphogenesis activity versus THAP12 in STOMACH (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	THAP12 →	+1.205	+1.874	.006	.007	3	4
LUNG_SCLC	MSMP →	+0.405	+1.402	<.001	<.001	3	3
LUNG_SCLC	CPE →	+2.946	+1.792	<.001	<.001	3	3
LUNG_SCLC	VPS29 →	+0.540	+0.894	.001	.001	3	3
LUNG_SCLC	DUSP4 →	+1.773	+1.106	<.001	<.001	3	3
LUNG_SCLC	REM2 →	+1.227	+1.394	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003214 vs THAP12 — STOMACH

Explore this scatter interactively →