Cardiac left ventricle morphogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Cardiac left ventricle morphogenesis pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 16 member genes.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher Cardiac left ventricle morphogenesis pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUAD and HNSC, show the opposite pattern, with higher activity associated with better survival.

LUAD, HNSC, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.769	0.600	.002	55	view →
HNSC	OS	Median	III,IV	0.457	0.318	.007	34	view →
LGG	OS	Tertile	All	0.901	0.740	<.001	33	view →
STAD	DFS	Quartile	All	0.418	0.574	.010	28	view →
CESC	DFS	Quartile	II,III,IV	0.623	0.826	.006	22	view →
LAML	DFS	Quartile	All	0.631	0.316	.006	18	view →
ACC	DFS	Quartile	III,IV	0.050	0.528	.004	18	view →
THYM	DFS	Tertile	III,IV	1.000	0.220	.011	15	view →
CHOL	DFS	Median	All	0.757	0.204	.015	15	view →
KIRP	DFS	Quartile	All	0.971	0.855	.013	13	view →
UCS	DFS	Tertile	IV	0.885	0.338	.024	12	view →
ESCA	DFS	Quartile	III,IV	0.457	0.194	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0003214–LUAD (OS)

Open the LUAD breakdown →