Cardiac atrium morphogenesis

Across TCGA patient cohorts, RNA activity of the Cardiac atrium morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH1B1, ASAP1, and STON1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac atrium morphogenesis activity versus ALDH1B1 in BRCA (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ALDH1B1 →	+0.475	+0.228	.004	.002	3	5
BRCA	ASAP1 →	+0.516	+0.262	.002	<.001	3	5
BRCA	STON1 →	+0.534	+0.340	.004	<.001	3	5
UCEC	SLC16A10 →	+1.000	+0.786	<.001	.001	3	4
PDAC	CYTOR →	+0.385	+0.282	.005	.001	3	4
HNSC	SUGT1P4-STRA6LP →	+0.627	+0.234	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003209 vs ALDH1B1 — BRCA

Explore this scatter interactively →