Cardiac atrium morphogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Cardiac atrium morphogenesis pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 29 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Cardiac atrium morphogenesis pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and THYM, show the opposite pattern, with higher activity associated with better survival.

ACC, STAD, and LIHC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.472	0.826	<.001	89	view →
STAD	DFS	Quartile	II,III,IV	0.511	0.726	.001	68	view →
LIHC	DFS	Quartile	II,III,IV	0.216	0.553	<.001	34	view →
SARC	DFS	Tertile	All	0.374	0.709	<.001	27	view →
KIRC	DFS	Quartile	All	0.962	0.861	.006	26	view →
THYM	DFS	Quartile	II,III,IV	0.945	0.684	.007	25	view →
HNSC	DFS	Quartile	All	0.779	0.628	.005	23	view →
SKCM	DFS	Median	III,IV	0.486	0.693	.002	19	view →
GBM	DFS	Tertile	All	0.331	0.177	.002	18	view →
UCEC	DFS	Median	All	0.729	0.582	.009	12	view →
UVM	OS	Tertile	II,III,IV	0.495	0.936	.014	12	view →
KIRP	OS	Tertile	All	0.937	0.569	.021	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0003209–ACC (DFS)

Open the ACC breakdown →