Cardiac chamber development

Across TCGA patient cohorts, RNA activity of the Cardiac chamber development pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNRPB, UBL4A, and PTGR1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac chamber development activity versus SNRPB in CCRCC (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SNRPB →	-0.344	-0.569	<.001	<.001	3	3
OV	UBL4A →	-0.841	-0.865	<.001	.007	3	2
BRCA	PTGR1 →	+0.838	+0.565	<.001	.004	3	2
COAD	BIN2P1 →	+0.065	+0.336	.002	.003	3	2
CCRCC	BAK1 →	-0.564	-0.492	.002	.007	3	2
COAD	MRPL22 →	-0.494	-0.266	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003205 vs SNRPB — CCRCC

Explore this scatter interactively →