Q-omics provides the consensus-scored BIN2P1 profile across patient tissues and cancer cell-line models. BIN2P1 expression is associated with patient survival in 18 of 34 cancer types, with the highest sampling consensus in SKCM. Among the 18 cancer types available for tumor–normal comparison, BIN2P1 is differentially expressed in 4, with the highest sampling consensus in KIRC. Additionally, BIN2P1 RNA expression shows 9,962 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight SKCM, KIRC, and THYM as cancer lineages where BIN2P1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for BIN2P1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes BIN2P1 survival associations across molecular data types. BIN2P1 RNA expression shows survival associations in the most cancer types (18). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible BIN2P1 RNA expression–survival associations across cancer types. High BIN2P1 expression shows unfavorable associations in MESO and OV, but favorable associations in SKCM, LUAD, CESC and HNSC. The SKCM Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .001). Together, the overview and detailed table identify SKCM as the clearest survival context for BIN2P1 RNA expression.
This table summarizes BIN2P1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 4. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for BIN2P1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. BIN2P1 shows lower tumor expression in LUSC and higher tumor expression in KIRC, HNSC and BLCA. The KIRC box plot shows higher BIN2P1 RNA expression in tumor versus normal tissue (log2 FC = +0.080, t-test p < 0.001).
This table shows molecular features associated with BIN2P1 in patient tissues and cancer cell lines. In patient samples, BIN2P1 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
