Heart valve formation

Across TCGA patient cohorts, RNA activity of the Heart valve formation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLN2, CACNA2D1, and FKBP7, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heart valve formation activity versus TLN2 in BRCA (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TLN2 →	+0.577	+0.052	<.001	<.001	3	9
COAD	CACNA2D1 →	+0.631	+0.057	<.001	<.001	3	8
OV	FKBP7 →	+0.658	+0.073	<.001	<.001	3	8
BRCA	LRP1 →	+0.527	+0.051	<.001	<.001	3	8
BRCA	PRKG1 →	+0.526	+0.049	<.001	<.001	3	8
HNSC	SNX9 →	+0.273	+0.055	<.001	.009	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003188 vs TLN2 — BRCA

Explore this scatter interactively →