Heart valve formation

Across TCGA patient cohorts, RNA activity of the Heart valve formation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are URI1_T492, GULP1, and TNS2_T615, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heart valve formation activity versus URI1_T492 in UCEC (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	URI1_T492 →	-0.582	-0.622	<.001	<.001	3	4
UCEC	GULP1 →	+0.449	+0.506	<.001	.001	3	4
OV	TNS2_T615 →	+1.091	+1.091	<.001	<.001	3	3
OV	WDR47_S312 →	+1.332	+1.280	<.001	<.001	3	3
HNSC	CALD1_S759 →	+0.656	+0.669	<.001	<.001	3	3
UCEC	MAP7_T277 →	-0.510	-0.581	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003188 vs URI1_T492 — UCEC

Explore this scatter interactively →