Tricuspid valve morphogenesis

Across TCGA patient cohorts, RNA activity of the Tricuspid valve morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GASK1B, KAT6B, and TGFBR2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tricuspid valve morphogenesis activity versus GASK1B in OV (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GASK1B →	+0.859	+0.197	<.001	.004	3	4
GBM	KAT6B →	+0.273	+0.132	.004	.003	3	3
CCRCC	TGFBR2 →	+0.403	+0.339	.005	.007	3	3
CCRCC	FOCAD-AS1 →	+0.531	+0.267	<.001	.005	3	3
CCRCC	RPS26P21 →	+0.631	+0.366	.001	.003	3	3
CCRCC	RPL15P21 →	+0.190	+0.196	.005	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003186 vs GASK1B — OV

Explore this scatter interactively →