Aortic valve morphogenesis

Across TCGA patient cohorts, RNA activity of the Aortic valve morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNX9, TNS2_S120, and HSPG2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aortic valve morphogenesis activity versus SNX9 in OV (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SNX9 →	+0.474	+0.079	<.001	<.001	3	10
LSCC	TNS2_S120 →	+0.502	+0.057	<.001	<.001	3	10
BRCA	HSPG2 →	+0.552	+0.066	<.001	<.001	3	10
UCEC	JCAD →	+0.447	+0.061	<.001	<.001	3	10
CCRCC	LMCD1 →	+0.814	+0.109	<.001	<.001	3	10
CCRCC	PALM2AKAP2 →	+0.652	+0.119	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003180 vs SNX9 — OV

Explore this scatter interactively →