Tricuspid valve development

Across TCGA patient cohorts, RNA activity of the Tricuspid valve development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MACROH2A2, ARHGEF17_S1331, and NHLRC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tricuspid valve development activity versus MACROH2A2 in GBM (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MACROH2A2 →	+0.637	+0.077	.001	.008	3	5
CCRCC	ARHGEF17_S1331 →	+0.487	+0.099	<.001	<.001	3	5
GBM	NHLRC2 →	+0.259	+0.090	<.001	.001	3	5
CCRCC	MIOS_S766 →	-0.320	-0.079	.002	<.001	3	5
UCEC	TTI1 →	-0.215	-0.122	<.001	<.001	3	5
UCEC	DNMT1_S714 →	-0.536	-0.154	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003175 vs MACROH2A2 — GBM

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