Tricuspid valve development

Across TCGA patient cohorts, RNA activity of the Tricuspid valve development pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL1RAPL1, RFX3-AS1, and FOCAD-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tricuspid valve development activity versus IL1RAPL1 in OV (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IL1RAPL1 →	+0.183	+0.224	.003	.002	3	4
UCEC	RFX3-AS1 →	+0.618	+0.202	.004	.001	3	3
CCRCC	FOCAD-AS1 →	+0.541	+0.275	<.001	.003	3	3
LSCC	SHC3 →	+0.454	+0.175	.001	.004	3	3
LSCC	SGMS2 →	+0.495	+0.161	<.001	.001	3	3
LSCC	SPRY1 →	+0.418	+0.179	.004	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003175 vs IL1RAPL1 — OV

Explore this scatter interactively →