Tricuspid valve development

Across TCGA cell cohorts, RNA activity of the Tricuspid valve development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BBC3, GPR156, and CRACR2A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BBC3 grouped by Tricuspid valve development-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BBC3 →	+2.054	+1.146	.001	.003	3	4
STOMACH	GPR156 →	-0.413	-1.357	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	CRACR2A →	-1.551	-1.205	.006	.003	3	4
OVARY	SURF4 →	+0.528	+0.537	.005	.009	3	3
BLOOD_Myeloma	CEP57L1 →	+0.952	+1.305	.005	.004	2	4
BLOOD_Leukemia	HMGCL →	+1.026	+1.205	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BBC3 by Tricuspid valve development activity — BLOOD_Leukemia

Explore this box plot interactively →