Tricuspid valve development

Across TCGA cell cohorts, RNA activity of the Tricuspid valve development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BMPR2, TGFBR2, and ITGB1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tricuspid valve development activity versus BMPR2 in SOFT_TISSUE (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	BMPR2 →	+1.123	+0.181	<.001	<.001	3	14
BONE	TGFBR2 →	+2.242	+0.739	<.001	<.001	3	12
BONE	ITGB1 →	+1.880	+1.202	<.001	<.001	3	11
BLOOD_Lymphoma	BMPR1A →	+0.837	+0.558	<.001	<.001	3	9
BONE	C5orf15 →	+0.871	+0.923	<.001	<.001	3	8
BONE	STT3B →	+0.803	+0.971	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003175 vs BMPR2 — SOFT_TISSUE

Explore this scatter interactively →