Mitral valve development

Across TCGA patient cohorts, RNA activity of the Mitral valve development pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AMY2B, IGFBP5, and TCF4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitral valve development activity versus AMY2B in COAD (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	AMY2B →	+0.557	+0.344	.001	.001	3	4
BRCA	IGFBP5 →	+1.130	+0.207	.005	.002	3	3
GBM	TCF4 →	+0.570	+0.383	<.001	.001	3	3
COAD	SATB2 →	+0.667	+0.233	.001	.001	3	3
LSCC	C1orf216 →	+0.386	+0.379	.003	.002	3	3
GBM	ZEB1 →	+0.579	+0.338	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003174 vs AMY2B — COAD

Explore this scatter interactively →