Atrioventricular valve development

Across TCGA patient cohorts, RNA activity of the Atrioventricular valve development pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN4, SGCD, and VCL, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Atrioventricular valve development activity versus SEPTIN4 in CCRCC (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SEPTIN4 →	+0.528	+0.101	<.001	<.001	3	9
BRCA	SGCD →	+0.797	+0.061	<.001	<.001	3	9
CCRCC	VCL →	+0.483	+0.089	<.001	<.001	3	9
OV	CD248 →	+0.600	+0.045	<.001	<.001	3	9
BRCA	CNRIP1 →	+0.629	+0.050	<.001	<.001	3	9
OV	FKBP7 →	+0.652	+0.062	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003171 vs SEPTIN4 — CCRCC

Explore this scatter interactively →