Atrioventricular valve development

Across TCGA cell cohorts, RNA activity of the Atrioventricular valve development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CMTM7, WFDC3, and HINT3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CMTM7 grouped by Atrioventricular valve development-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CMTM7 →	-2.765	-1.265	.004	.003	3	5
OVARY	WFDC3 →	-1.585	-1.244	.006	.001	3	4
LUNG_SCLC	HINT3 →	+0.962	+0.945	.002	.003	3	4
CNS	FAM102B →	+1.054	+0.793	.004	.006	3	4
UPPER_AERODIGESTIVE_TRACT	IDH1 →	+1.420	+1.422	.008	<.001	3	4
KIDNEY	GPR156 →	-0.422	-1.240	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CMTM7 by Atrioventricular valve development activity — LUNG_SCLC

Explore this box plot interactively →