Atrioventricular valve development

Across TCGA cell cohorts, RNA activity of the Atrioventricular valve development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF562, GTF2H1, and HERPUD2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Atrioventricular valve development activity versus ZNF562 in OVARY (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ZNF562 →	+0.881	+0.448	.002	.003	3	3
CNS	GTF2H1 →	-0.780	-0.372	.002	.001	3	3
CNS	HERPUD2 →	-0.848	-0.330	.006	.005	3	3
CNS	UEVLD →	-0.548	-0.260	.009	.007	3	3
LUNG_NSCLC_LUAD	TP53 →	-2.065	-0.434	.003	.005	3	3
LUNG_NSCLC_LUAD	ATG16L1 →	-0.951	-0.411	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003171 vs ZNF562 — OVARY

Explore this scatter interactively →