Atrioventricular node development

Across TCGA cell cohorts, RNA activity of the Atrioventricular node development pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS11, RPL27, and SNRPG, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS11 grouped by Atrioventricular node development-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RPS11 →	+0.650	+1.240	.003	.001	3	5
CNS	RPL27 →	+0.768	+1.066	.003	<.001	3	4
OVARY	SNRPG →	+0.653	+1.121	<.001	<.001	3	4
BLOOD_Leukemia	NHEJ1 →	+0.941	+0.844	<.001	.009	3	4
KIDNEY	KLHL30 →	+0.352	+1.460	.004	.001	3	4
STOMACH	MX1 →	-2.112	-1.116	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS11 by Atrioventricular node development activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →