Negative regulation of systemic arterial blood pressure

Across TCGA cell cohorts, RNA activity of the Negative regulation of systemic arterial blood pressure pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM220, ADGRG1, and BPHL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM220 grouped by Negative regulation of systemic arterial blood pressure-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TMEM220 →	+1.119	+1.292	.003	.004	3	4
SOFT_TISSUE	ADGRG1 →	-3.272	-1.609	.009	.001	3	4
BLOOD_Lymphoma	BPHL →	+2.043	+1.982	.008	<.001	3	4
STOMACH	COX8A →	+0.491	+1.003	.005	.006	3	4
OESOPHAGUS	ARL17A →	+1.057	+0.754	.004	.004	3	4
BREAST	OR2C1 →	+0.049	+0.815	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM220 by Negative regulation of systemic arterial blood pressure activity — PANCREAS

Explore this box plot interactively →