Respiratory system process

Across TCGA patient cohorts, RNA activity of the Respiratory system process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NMU, NABP1, and SCN1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Respiratory system process activity versus NMU in CCRCC (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	NMU →	-1.395	-0.683	<.001	.001	3	4
CCRCC	NABP1 →	-0.478	-0.567	<.001	<.001	3	4
CCRCC	SCN1B →	+0.439	+0.418	.001	.006	3	3
CCRCC	CD80 →	-0.755	-0.957	<.001	<.001	3	3
BRCA	FAM47E →	+0.385	+0.388	.007	.002	3	3
HNSC	SNORD114-24 →	+1.038	+0.826	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003016 vs NMU — CCRCC

Explore this scatter interactively →