Respiratory system process

Across TCGA pan-cancer cohorts, RNA activity of the Respiratory system process pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 38 member genes.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher Respiratory system process pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUAD and UCS, show the opposite pattern, with higher activity associated with better survival.

LUAD, COAD, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.525	0.314	<.001	61	view →
COAD	DFS	Quartile	All	0.691	0.836	.001	49	view →
KIRC	DFS	Tertile	All	0.474	0.692	<.001	48	view →
LIHC	OS	Median	II,III,IV	0.228	0.549	<.001	47	view →
UCEC	DFS	Tertile	II,III,IV	0.519	0.777	.009	34	view →
THYM	OS	Quartile	II,III,IV	0.856	1.000	.013	24	view →
BRCA	DFS	Quartile	IV	0.451	0.977	.005	21	view →
UCS	DFS	Tertile	II,III,IV	0.477	0.149	.016	14	view →
MESO	DFS	Tertile	IV	0.651	0.227	.031	12	view →
READ	DFS	Median	III,IV	0.470	0.864	.004	9	view →
ESCA	OS	Median	All	1.000	0.629	.012	8	view →
PAAD	DFS	Median	II,III,IV	0.458	0.299	.021	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0003016–LUAD (OS)

Open the LUAD breakdown →