Heart morphogenesis

Across TCGA patient cohorts, RNA activity of the Heart morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the KICH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MACF1, HSPG2, and DDR2, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heart morphogenesis activity versus MACF1 in KICH (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KICH	MACF1 →	+1.049	+0.020	<.001	<.001	3	33
CHOL	HSPG2 →	+2.377	+0.040	<.001	<.001	3	33
CHOL	DDR2 →	+1.696	+0.038	<.001	<.001	3	33
HNSC	FBN1 →	+2.070	+0.034	<.001	<.001	3	33
MESO	DCHS1 →	+1.450	+0.036	<.001	<.001	3	33
THYM	PEAK1 →	+1.444	+0.053	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003007 vs MACF1 — KICH

Explore this scatter interactively →