Heart morphogenesis

Across TCGA patient cohorts, RNA activity of the Heart morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IKBKB, PLEKHA8, and RANGRF, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heart morphogenesis activity versus IKBKB in COAD (Pearson r = -0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IKBKB →	+0.796	+0.626	.002	.009	3	1
COAD	PLEKHA8 →	+0.489	+0.625	.001	.009	3	1
COAD	RANGRF →	-0.588	-0.626	.001	.009	3	1
COAD	TENT5A →	-0.928	-0.626	.006	.009	3	1
COAD	NT5C1A →	+0.333	+0.816	<.001	<.001	3	1
COAD	BMP15 →	+0.110	+0.799	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003007 vs IKBKB — COAD

Explore this scatter interactively →