Heart morphogenesis

Across TCGA cell cohorts, RNA activity of the Heart morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IQGAP3, ATF3, and TMEM100, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IQGAP3 grouped by Heart morphogenesis-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	IQGAP3 →	+0.124	+0.721	<.001	.005	3	3
LIVER	ATF3 →	+0.178	+0.187	.004	.008	3	3
LUNG_NSCLC_LUSC	TMEM100 →	+0.236	+0.334	.002	.008	3	3
LUNG_SCLC	IL22RA2 →	+0.231	+0.288	.001	.003	3	3
SOFT_TISSUE	ATP10D →	-0.293	-1.779	<.001	<.001	3	3
BREAST	IFNA21 →	+0.150	+0.183	.005	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IQGAP3 by Heart morphogenesis activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →