Heart morphogenesis

Across TCGA cell cohorts, RNA activity of the Heart morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYO1D, BCORL1, and FXYD3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heart morphogenesis activity versus MYO1D in LUNG_NSCLC_LUAD (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MYO1D →	+1.411	+0.683	.003	.002	3	6
LUNG_NSCLC_LUAD	BCORL1 →	-0.816	-0.583	.003	.003	3	4
LUNG_NSCLC_LUAD	FXYD3 →	+3.050	+0.516	<.001	<.001	3	4
BREAST	PMP22 →	-2.780	-0.244	<.001	<.001	3	4
LUNG_NSCLC_LUAD	PERP →	+1.558	+0.720	<.001	.001	3	4
LUNG_NSCLC_LUAD	ST14 →	+2.858	+0.535	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003007 vs MYO1D — LUNG_NSCLC_LUAD

Explore this scatter interactively →