Negative regulation of B cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of B cell apoptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNKS1BP1, CTNND1, and PKN1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of B cell apoptotic process activity versus TNKS1BP1 in HNSC (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TNKS1BP1 →	-0.371	-0.088	<.001	<.001	3	7
HNSC	CTNND1 →	-0.361	-0.083	<.001	<.001	3	7
HNSC	PKN1 →	+0.321	+0.058	<.001	.002	3	7
UCEC	SMCHD1 →	+0.315	+0.089	<.001	<.001	3	6
PDAC	ZC3H13_S993 →	+0.299	+0.046	<.001	<.001	3	6
HNSC	GNG12 →	-0.280	-0.059	.004	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002903 vs TNKS1BP1 — HNSC

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