Negative regulation of B cell apoptotic process

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of B cell apoptotic process pathway differs between tumor and matched normal tissue in 12 of the 18 cancer types tested.

The strongest signal is observed in lung adenocarcinoma (LUAD), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KIRC and THCA, show the opposite pattern, with lower activity in tumor tissue.

LUAD, HNSC, and STAD show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
LUAD	Male	II,III,IV	+0.106	<.001	11	view →
HNSC	All	III,IV	+0.042	<.001	8	view →
STAD	All	II,III,IV	+0.057	.004	6	view →
COAD	Female	All	+0.032	.002	6	view →
LIHC	Male	II,III,IV	+0.059	.003	5	view →
LUSC	All	All	+0.046	<.001	5	view →
KIRC	Female	All	−0.035	<.001	5	view →
CHOL	Male	All	+0.110	<.001	4	view →
THCA	All	All	−0.029	.002	2	view →
PAAD	Male	All	+0.025	.037	2	view →
READ	All	II,III,IV	+0.040	.030	1	view →
KIRP	All	III,IV	+0.034	.045	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 12 lineages.

GO:0002903–LUAD

Open the LUAD breakdown →