Negative regulation of B cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of B cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRS2, DNAJC8, and FCHO1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of B cell apoptotic process activity versus IRS2 in UCEC (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IRS2 →	+1.222	+1.114	<.001	<.001	3	8
CCRCC	DNAJC8 →	-0.191	-0.701	.002	.001	3	5
CCRCC	FCHO1 →	+0.520	+0.764	<.001	<.001	3	5
LUAD	HLF →	-1.070	-0.659	.001	.002	3	4
GBM	FAAH →	-0.861	-0.303	<.001	<.001	3	4
LUAD	KRTAP5-AS1 →	-0.459	-0.473	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002903 vs IRS2 — UCEC

Explore this scatter interactively →