Negative regulation of B cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of B cell apoptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MIF, PCNP, and PAFAH1B3, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of B cell apoptotic process activity versus MIF in LUNG_NSCLC_LUSC (Pearson r = 0.79).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MIF →	+2.617	+0.257	.002	<.001	3	12
LUNG_NSCLC_LUSC	PCNP →	+1.681	+0.215	<.001	<.001	3	8
BREAST	PAFAH1B3 →	+1.808	+0.236	.001	<.001	3	7
OESOPHAGUS	GLO1 →	+1.598	+0.094	.007	.006	2	8
URINARY_TRACT	PPA1 →	+2.756	+0.345	.002	.006	3	7
SKIN	GRHPR →	+0.530	+0.135	.008	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002903 vs MIF — LUNG_NSCLC_LUSC

Explore this scatter interactively →