Regulation of B cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Regulation of B cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRS2, RARRES1, and DDAH1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of B cell apoptotic process activity versus IRS2 in UCEC (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IRS2 →	+1.227	+1.018	<.001	<.001	3	7
CCRCC	RARRES1 →	+0.920	+0.644	<.001	<.001	3	5
CCRCC	DDAH1 →	-0.782	-0.813	<.001	<.001	3	5
LUAD	HLF →	-0.938	-0.573	.004	.003	3	4
GBM	RAPGEF5 →	-0.915	-0.318	.003	.005	3	4
LUAD	TMEM63C →	-1.039	-0.584	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002902 vs IRS2 — UCEC

Explore this scatter interactively →