Regulation of B cell apoptotic process

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of B cell apoptotic process pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 21 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Regulation of B cell apoptotic process pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ESCA and SKCM, show the opposite pattern, with higher activity associated with better survival.

KIRC, KIRP, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.540	0.703	<.001	111	view →
KIRP	OS	Tertile	All	0.579	0.833	<.001	85	view →
ACC	DFS	Tertile	III,IV	0.055	0.531	<.001	68	view →
LIHC	OS	Tertile	All	0.570	0.756	<.001	68	view →
ESCA	OS	Quartile	II,III,IV	0.656	0.288	.001	49	view →
SKCM	OS	Median	All	0.866	0.708	.003	46	view →
BLCA	OS	Tertile	III,IV	0.749	0.395	<.001	45	view →
BRCA	DFS	Median	All	0.598	0.480	.002	39	view →
DLBC	DFS	Tertile	IV	0.129	0.914	.004	38	view →
COAD	OS	Quartile	III,IV	0.323	0.769	.004	38	view →
LGG	OS	Tertile	All	0.422	0.587	.001	28	view →
HNSC	DFS	Quartile	III,IV	0.465	0.296	.011	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0002902–KIRC (OS)

Open the KIRC breakdown →