Regulation of B cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Regulation of B cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYFIP2, CGAS, and GRK4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of B cell apoptotic process activity versus CYFIP2 in LUNG_NSCLC_LUSC (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CYFIP2 →	+2.979	+0.208	<.001	.001	3	5
SKIN	CGAS →	-1.701	-0.175	.003	.003	3	5
SKIN	GRK4 →	+0.594	+0.123	.006	.003	3	4
SKIN	ARL6IP6 →	-0.615	-0.118	.008	.003	3	4
BLOOD_Lymphoma	LYL1 →	-3.074	-0.197	.001	.007	3	4
BLOOD_Lymphoma	NEK8 →	-0.859	-0.201	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002902 vs CYFIP2 — LUNG_NSCLC_LUSC

Explore this scatter interactively →