Positive regulation of T cell mediated immune response to tumor cell

Across TCGA patient cohorts, RNA activity of the Positive regulation of T cell mediated immune response to tumor cell pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP1, RNASEL, and SH3BGRL, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T cell mediated immune response to tumor cell activity versus TOP1 in UCEC (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TOP1 →	-0.360	-0.082	<.001	<.001	3	9
UCEC	RNASEL →	+0.396	+0.092	<.001	<.001	3	8
BRCA	SH3BGRL →	+0.431	+0.043	<.001	<.001	3	8
GBM	UBA7 →	+0.529	+0.096	<.001	<.001	3	8
BRCA	MRTO4 →	-0.354	-0.066	<.001	<.001	3	8
LUAD	TOP2A →	-0.925	-0.079	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002842 vs TOP1 — UCEC

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