Positive regulation of T cell mediated immune response to tumor cell

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of T cell mediated immune response to tumor cell pathway is associated with patient survival in 30 of 34 cancer lineages. Pathway activity is summarized from the expression of its 6 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Positive regulation of T cell mediated immune response to tumor cell pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and LUAD, show the opposite pattern, with higher activity associated with better survival.

UVM, SKCM, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	III,IV	0.233	0.712	.004	71	view →
SKCM	OS	Median	All	0.830	0.736	.001	52	view →
LGG	OS	Median	All	0.342	0.544	<.001	50	view →
KIRP	DFS	Median	All	0.790	0.909	.004	44	view →
LUAD	OS	Tertile	All	0.870	0.763	.001	41	view →
BLCA	DFS	Quartile	III,IV	0.610	0.265	.012	34	view →
MESO	OS	Quartile	All	0.652	0.350	.001	31	view →
STAD	DFS	Quartile	All	0.431	0.691	.001	31	view →
READ	DFS	Median	IV	0.329	0.767	.001	21	view →
GBM	DFS	Median	All	0.170	0.365	<.001	18	view →
LAML	DFS	Quartile	All	0.295	0.619	.015	16	view →
TGCT	DFS	Median	All	0.764	0.898	.016	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

GO:0002842–UVM (DFS)

Open the UVM breakdown →