Positive regulation of T cell mediated immune response to tumor cell

Across TCGA cell cohorts, RNA activity of the Positive regulation of T cell mediated immune response to tumor cell pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEK2, MED6, and MAGOH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NEK2 grouped by Positive regulation of T cell mediated immune response to tumor cell-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NEK2 →	+0.682	+0.272	<.001	<.001	3	4
OVARY	MED6 →	+0.619	+0.264	.001	.002	3	4
SKIN	MAGOH →	+0.424	+0.129	<.001	.009	3	4
SKIN	LYRM9 →	-0.655	-0.228	.004	<.001	3	4
CNS	PXYLP1 →	-1.263	-0.186	<.001	.004	3	4
KIDNEY	LARS1 →	+0.540	+0.658	.003	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NEK2 by Positive regulation of T cell mediated immune response to tumor cell activity — SKIN

Explore this box plot interactively →