Negative regulation of type 2 immune response

Across TCGA patient cohorts, RNA activity of the Negative regulation of type 2 immune response pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTAFR, RNU6-140P, and TRPV4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of type 2 immune response activity versus PTAFR in UCEC (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PTAFR →	+0.757	+0.552	<.001	<.001	3	4
LSCC	RNU6-140P →	+1.221	+0.564	.001	.001	3	4
GBM	TRPV4 →	+0.553	+0.892	<.001	<.001	3	4
BRCA	CEP170 →	-0.459	-0.525	.002	.004	3	4
BRCA	TSPYL4 →	-0.699	-0.720	<.001	<.001	3	4
HNSC	FAM83C →	+1.079	+0.268	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002829 vs PTAFR — UCEC

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