Negative regulation of type 2 immune response

Across TCGA cell cohorts, RNA activity of the Negative regulation of type 2 immune response pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEU1, BNC1, and CPA6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NEU1 grouped by Negative regulation of type 2 immune response-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	NEU1 →	-0.121	-0.140	.002	<.001	3	4
LUNG_NSCLC_LUSC	BNC1 →	+0.161	+0.110	.003	.005	2	5
BLOOD_Leukemia	CPA6 →	-0.165	-0.966	<.001	<.001	3	4
SOFT_TISSUE	CTDNEP1 →	-0.224	-0.166	<.001	.007	3	4
OESOPHAGUS	BYSL →	-0.204	-0.149	.003	.006	3	3
OESOPHAGUS	ARHGAP9 →	+0.310	+0.157	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NEU1 by Negative regulation of type 2 immune response activity — OESOPHAGUS

Explore this box plot interactively →