Negative regulation of type 2 immune response

Across TCGA cell cohorts, RNA activity of the Negative regulation of type 2 immune response pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA1, TIMP1, and GPX8, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of type 2 immune response activity versus ANXA1 in LUNG_SCLC (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ANXA1 →	+6.721	+0.802	<.001	.001	3	13
BLOOD_Lymphoma	TIMP1 →	+4.319	+0.510	<.001	.001	2	10
BREAST	GPX8 →	+2.903	+0.606	<.001	<.001	3	9
BREAST	FOSL1 →	+3.394	+0.591	<.001	<.001	3	9
LIVER	LGALS1 →	+3.627	+0.145	.002	.002	2	9
LUNG_NSCLC_LUAD	EMP3 →	+2.008	+0.100	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002829 vs ANXA1 — LUNG_SCLC

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