Negative regulation of type 2 immune response

Across TCGA cell cohorts, RNA activity of the Negative regulation of type 2 immune response pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HERC1, STMN2, and PBX4, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of type 2 immune response activity versus HERC1 in LUNG_SCLC (Pearson r = -0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HERC1 →	-1.123	-1.976	.001	<.001	3	1
LUNG_SCLC	STMN2 →	-4.449	-1.557	.008	.005	3	1
LUNG_SCLC	PBX4 →	-1.702	-1.607	<.001	.004	3	1
LUNG_SCLC	ELP4 →	-1.413	-2.097	.005	<.001	3	1
LUNG_SCLC	STX2 →	-1.121	-1.212	.002	.008	3	1
LUNG_SCLC	GNB3 →	-1.603	-1.212	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002829 vs HERC1 — LUNG_SCLC

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