Negative regulation of myeloid leukocyte differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of myeloid leukocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR65, FCER1G, and SLC31A2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of myeloid leukocyte differentiation activity versus GPR65 in GBM (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GPR65 →	+0.638	+0.260	<.001	<.001	3	6
GBM	FCER1G →	+0.737	+0.238	<.001	<.001	3	6
GBM	SLC31A2 →	+0.507	+0.180	<.001	<.001	3	5
GBM	CMTM7 →	+0.487	+0.193	<.001	<.001	3	5
HNSC	GCAT →	-0.961	-0.183	<.001	<.001	3	5
UCEC	TNFSF14 →	+0.779	+0.258	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002762 vs GPR65 — GBM

Explore this scatter interactively →